BDBM19360 2,4-diaminopyrimidine-based antagonist, 13f::N-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5-yl}phenyl)-N-methylcyclopentanecarboxamide

SMILES: CN(C(=O)C1CCCC1)c1ccc(cc1)-c1c(N)nc(N)nc1COCc1ccccc1

InChI Key: InChIKey=VRFGCTMNTASNRG-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 19360   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ghrelin receptor (Homo sapiens (Human))	BDBM19360 (2,4-diaminopyrimidine-based antagonist, 13f | N-(4...) Show SMILES CN(C(=O)C1CCCC1)c1ccc(cc1)-c1c(N)nc(N)nc1COCc1ccccc1 Show InChI InChI=1S/C25H29N5O2/c1-30(24(31)19-9-5-6-10-19)20-13-11-18(12-14-20)22-21(28-25(27)29-23(22)26)16-32-15-17-7-3-2-4-8-17/h2-4,7-8,11-14,19H,5-6,9-10,15-16H2,1H3,(H4,26,27,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.67E+3	n/a	>1.00E+4	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...				J Med Chem 49: 4459-69 (2006) Article DOI: 10.1021/jm060461g BindingDB Entry DOI: 10.7270/Q2CN726R
					More data for this Ligand-Target Pair