BDBM19363 2,4-diaminopyrimidine-based antagonist, 13j::N-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5-yl}phenyl)thiophene-3-carboxamide

SMILES: Nc1nc(N)c(c(COCc2ccccc2)n1)-c1ccc(NC(=O)c2ccsc2)cc1

InChI Key: InChIKey=WMIRSHGNCSPTIB-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 19363   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ghrelin receptor (Homo sapiens (Human))	BDBM19363 (2,4-diaminopyrimidine-based antagonist, 13j | N-(4...) Show SMILES Nc1nc(N)c(c(COCc2ccccc2)n1)-c1ccc(NC(=O)c2ccsc2)cc1 Show InChI InChI=1S/C23H21N5O2S/c24-21-20(16-6-8-18(9-7-16)26-22(29)17-10-11-31-14-17)19(27-23(25)28-21)13-30-12-15-4-2-1-3-5-15/h1-11,14H,12-13H2,(H,26,29)(H4,24,25,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	126	n/a	>1.00E+4	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...				J Med Chem 49: 4459-69 (2006) Article DOI: 10.1021/jm060461g BindingDB Entry DOI: 10.7270/Q2CN726R
					More data for this Ligand-Target Pair