BDBM19374 2,4-diaminopyrimidine-based antagonist, 14g::3-(4-{2,4-diamino-6-[(benzyloxy)methyl]pyrimidin-5-yl}phenyl)-1-(2-phenylethyl)urea

SMILES: Nc1nc(N)c(c(COCc2ccccc2)n1)-c1ccc(NC(=O)NCCc2ccccc2)cc1

InChI Key: InChIKey=LGGIVTCQXBEAOP-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 19374   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ghrelin receptor (Homo sapiens (Human))	BDBM19374 (2,4-diaminopyrimidine-based antagonist, 14g | 3-(4...) Show SMILES Nc1nc(N)c(c(COCc2ccccc2)n1)-c1ccc(NC(=O)NCCc2ccccc2)cc1 Show InChI InChI=1S/C27H28N6O2/c28-25-24(23(32-26(29)33-25)18-35-17-20-9-5-2-6-10-20)21-11-13-22(14-12-21)31-27(34)30-16-15-19-7-3-1-4-8-19/h1-14H,15-18H2,(H2,30,31,34)(H4,28,29,32,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description Specific binding was determined by incubation of membranes from GHS-R1a transfected CHO-K cells with 125I-His9-ghrelin in the presence of increasing ...				J Med Chem 49: 4459-69 (2006) Article DOI: 10.1021/jm060461g BindingDB Entry DOI: 10.7270/Q2CN726R
					More data for this Ligand-Target Pair