BDBM194399 US9200016, 81::US9902710, Compound 81

SMILES: COc1cc2cncc(Cc3ccc4n(C)c(=O)oc4c3)c2cc1OC

InChI Key: InChIKey=ONPIQEOUWZRGHN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 194399   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194399 (US9200016, 81 | US9902710, Compound 81) Show SMILES COc1cc2cncc(Cc3ccc4n(C)c(=O)oc4c3)c2cc1OC Show InChI InChI=1S/C20H18N2O4/c1-22-16-5-4-12(7-17(16)26-20(22)23)6-13-10-21-11-14-8-18(24-2)19(25-3)9-15(13)14/h4-5,7-11H,6H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description The phosphodiesterase assay was developed using the LANCE® cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1.5...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q2PC34QT
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM194399 (US9200016, 81 | US9902710, Compound 81) Show SMILES COc1cc2cncc(Cc3ccc4n(C)c(=O)oc4c3)c2cc1OC Show InChI InChI=1S/C20H18N2O4/c1-22-16-5-4-12(7-17(16)26-20(22)23)6-13-10-21-11-14-8-18(24-2)19(25-3)9-15(13)14/h4-5,7-11H,6H2,1-3H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	7.4	37
Allergan, Inc.; Exonhit Therapeutics, SA US Patent					Assay Description The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....				US Patent US9200016 (2015) BindingDB Entry DOI: 10.7270/Q2ZC81PH
					More data for this Ligand-Target Pair