null
SMILES: NC(=O)c1cccc2n(cc(C[C@H](O)CO)c12)-c1ccc(Oc2ccc(F)cc2)cc1
InChI Key: InChIKey=WXUXQOGIRNAHNO-SFHVURJKSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM196476 (US10202344, Compound 122 | US9212139, 122) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 300 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Purdue Pharma, L.P. US Patent | Assay Description For electrophysiological recordings the external solution was either standard, DMEM supplemented with 10 mM HEPES (pH adjusted to 7.34 with NaOH and ... | US Patent US9212139 (2015) BindingDB Entry DOI: 10.7270/Q26Q1W19 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM196476 (US10202344, Compound 122 | US9212139, 122) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue Pharma L.P. US Patent | Assay Description Electrophysiology: On the day of experimentation, the 35 mm dish was placed on the stage of an inverted microscope equipped with a perfusion system t... | US Patent US10202344 (2019) BindingDB Entry DOI: 10.7270/Q2X350KJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM196476 (US10202344, Compound 122 | US9212139, 122) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 222 | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue Pharma L.P. US Patent | Assay Description Recombinant Nav1.7 Cell Line: In vitro assays were performed in a recombinant cell line expressing cDNA encoding the alpha subunit (Nav1.7, SCN9a, PN... | US Patent US10202344 (2019) BindingDB Entry DOI: 10.7270/Q2X350KJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human)) | BDBM196476 (US10202344, Compound 122 | US9212139, 122) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 222 | n/a | n/a | n/a | n/a | 7.3 | n/a |
Purdue Pharma, L.P. US Patent | Assay Description Assay Buffer: The assay buffer was formulated by removing 120 mL from a 1 L bottle of fresh, sterile dH2O (Mediatech, Herndon, Va.) and adding 100 mL... | US Patent US9212139 (2015) BindingDB Entry DOI: 10.7270/Q26Q1W19 | |||||||||||
More data for this Ligand-Target Pair |