BDBM197503 US9216968, 102::US9732066, 102

SMILES: COCc1nc2c(cc(NC(=O)c3c(Cl)cccc3Br)cc2[nH]1)C(=O)Nc1cccc(Cl)c1C

InChI Key: InChIKey=ATFASNHSCGXRFQ-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 197503   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E synthase (Homo sapiens (Human))	BDBM197503 (US9216968, 102 | US9732066, 102) Show SMILES COCc1nc2c(cc(NC(=O)c3c(Cl)cccc3Br)cc2[nH]1)C(=O)Nc1cccc(Cl)c1C Show InChI InChI=1S/C24H19BrCl2N4O3/c1-12-16(26)6-4-8-18(12)30-23(32)14-9-13(10-19-22(14)31-20(29-19)11-34-2)28-24(33)21-15(25)5-3-7-17(21)27/h3-10H,11H2,1-2H3,(H,28,33)(H,29,31)(H,30,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
NIPPON SHINY AKU CO., LTD. US Patent					Assay Description mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...				US Patent US9732066 (2017) BindingDB Entry DOI: 10.7270/Q2K35WSW
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM197503 (US9216968, 102 | US9732066, 102) Show SMILES COCc1nc2c(cc(NC(=O)c3c(Cl)cccc3Br)cc2[nH]1)C(=O)Nc1cccc(Cl)c1C Show InChI InChI=1S/C24H19BrCl2N4O3/c1-12-16(26)6-4-8-18(12)30-23(32)14-9-13(10-19-22(14)31-20(29-19)11-34-2)28-24(33)21-15(25)5-3-7-17(21)27/h3-10H,11H2,1-2H3,(H,28,33)(H,29,31)(H,30,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
NIPPON SHINYAKU CO., LTD. US Patent					Assay Description mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...				US Patent US9216968 (2015) BindingDB Entry DOI: 10.7270/Q2KS6QCQ
					More data for this Ligand-Target Pair