BDBM197590 US9216968, 190::US9732066, 190

SMILES: COCC(C)(C)CNc1nc2c(cc(NC(=O)c3cc(Cl)ccc3Cl)cc2[nH]1)C(=O)Nc1cccc(Cl)c1C

InChI Key: InChIKey=RKXCTVFBZIGHKN-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 197590   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E synthase (Homo sapiens (Human))	BDBM197590 (US9216968, 190 | US9732066, 190) Show SMILES COCC(C)(C)CNc1nc2c(cc(NC(=O)c3cc(Cl)ccc3Cl)cc2[nH]1)C(=O)Nc1cccc(Cl)c1C Show InChI InChI=1S/C28H28Cl3N5O3/c1-15-20(30)6-5-7-22(15)34-26(38)19-11-17(33-25(37)18-10-16(29)8-9-21(18)31)12-23-24(19)36-27(35-23)32-13-28(2,3)14-39-4/h5-12H,13-14H2,1-4H3,(H,33,37)(H,34,38)(H2,32,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
NIPPON SHINY AKU CO., LTD. US Patent					Assay Description mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...				US Patent US9732066 (2017) BindingDB Entry DOI: 10.7270/Q2K35WSW
					More data for this Ligand-Target Pair
Prostaglandin E synthase (Homo sapiens (Human))	BDBM197590 (US9216968, 190 | US9732066, 190) Show SMILES COCC(C)(C)CNc1nc2c(cc(NC(=O)c3cc(Cl)ccc3Cl)cc2[nH]1)C(=O)Nc1cccc(Cl)c1C Show InChI InChI=1S/C28H28Cl3N5O3/c1-15-20(30)6-5-7-22(15)34-26(38)19-11-17(33-25(37)18-10-16(29)8-9-21(18)31)12-23-24(19)36-27(35-23)32-13-28(2,3)14-39-4/h5-12H,13-14H2,1-4H3,(H,33,37)(H,34,38)(H2,32,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.100	n/a	n/a	n/a	n/a	n/a	n/a
NIPPON SHINYAKU CO., LTD. US Patent					Assay Description mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...				US Patent US9216968 (2015) BindingDB Entry DOI: 10.7270/Q2KS6QCQ
					More data for this Ligand-Target Pair