BDBM197689 US9216981, 17::US9550781, 24
SMILES: Fc1ccc(NS(=O)(=O)c2ccsc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12
InChI Key: InChIKey=YSBVTNXKLLPITL-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM197689![]() (US9216981, 17 | US9550781, 24) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 7 | n/a | n/a | n/a | n/a | 7.2 | 30 |
Medpacto, Inc. US Patent | Assay Description To check the B-Raf kinase inhibitory activity of the compounds of the present invention, the following experiments were conducted.(1) Serial Signalin... | US Patent US9216981 (2015) BindingDB Entry DOI: 10.7270/Q2BC3XCR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor coactivator 2 (aa 740-753) () | BDBM197689![]() (US9216981, 17 | US9550781, 24) | GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Centaurus Biopharma Co., Ltd.; Chia Tai Tianqing Pharmaceutical Group Co., Ltd. US Patent | Assay Description In vitro B-RAF Kinase Assay. To determine iIn vitro activities of recombinant B-RAF enzyme, a Homogeneous Time-Resolved Fluorescence (HTRF) assay was... | US Patent US9550781 (2017) BindingDB Entry DOI: 10.7270/Q2X63PXK | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase B-raf (Homo sapiens (Human)) | BDBM197689![]() (US9216981, 17 | US9550781, 24) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | 37 |
Medpacto, Inc. US Patent | Assay Description To check the B-Raf cell activity inhibitory capability of the compounds of the present invention, the following experiments were conducted in A375P... | US Patent US9216981 (2015) BindingDB Entry DOI: 10.7270/Q2BC3XCR | |||||||||||
More data for this Ligand-Target Pair |