BDBM197694 US9216981, 23

SMILES: Cc1ccc(o1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F

InChI Key: InChIKey=QIMUSZMFBWTWNO-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 197694   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM197694 (US9216981, 23) Show SMILES Cc1ccc(o1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F Show InChI InChI=1S/C21H15F2N7O3S/c1-11-4-7-15(33-11)34(31,32)30-14-6-5-13(22)18(16(14)23)29-20-12(3-2-8-24-20)17-19-21(27-9-25-17)28-10-26-19/h2-10,30H,1H3,(H,24,29)(H,25,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	60	n/a	n/a	n/a	37
Medpacto, Inc. US Patent					Assay Description To check the B-Raf cell activity inhibitory capability of the compounds of the present invention, the following experiments were conducted in A375P...				US Patent US9216981 (2015) BindingDB Entry DOI: 10.7270/Q2BC3XCR
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM197694 (US9216981, 23) Show SMILES Cc1ccc(o1)S(=O)(=O)Nc1ccc(F)c(Nc2ncccc2-c2ncnc3[nH]cnc23)c1F Show InChI InChI=1S/C21H15F2N7O3S/c1-11-4-7-15(33-11)34(31,32)30-14-6-5-13(22)18(16(14)23)29-20-12(3-2-8-24-20)17-19-21(27-9-25-17)28-10-26-19/h2-10,30H,1H3,(H,24,29)(H,25,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	7.2	30
Medpacto, Inc. US Patent					Assay Description To check the B-Raf kinase inhibitory activity of the compounds of the present invention, the following experiments were conducted.(1) Serial Signalin...				US Patent US9216981 (2015) BindingDB Entry DOI: 10.7270/Q2BC3XCR
					More data for this Ligand-Target Pair