null

SMILES: Fc1ccc(NS(=O)(=O)c2cccc3CCOc23)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12

InChI Key: InChIKey=HQLSNMHUQKMLRG-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 197707   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM197707 (US9216981, 36) Show SMILES Fc1ccc(NS(=O)(=O)c2cccc3CCOc23)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 Show InChI InChI=1S/C24H17F2N7O3S/c25-15-6-7-16(33-37(34,35)17-5-1-3-13-8-10-36-22(13)17)18(26)20(15)32-23-14(4-2-9-27-23)19-21-24(30-11-28-19)31-12-29-21/h1-7,9,11-12,33H,8,10H2,(H,27,32)(H,28,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8.37E+3	n/a	n/a	n/a	37
Medpacto, Inc. US Patent					Assay Description To check the B-Raf cell activity inhibitory capability of the compounds of the present invention, the following experiments were conducted in A375P...				US Patent US9216981 (2015) BindingDB Entry DOI: 10.7270/Q2BC3XCR
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM197707 (US9216981, 36) Show SMILES Fc1ccc(NS(=O)(=O)c2cccc3CCOc23)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 Show InChI InChI=1S/C24H17F2N7O3S/c25-15-6-7-16(33-37(34,35)17-5-1-3-13-8-10-36-22(13)17)18(26)20(15)32-23-14(4-2-9-27-23)19-21-24(30-11-28-19)31-12-29-21/h1-7,9,11-12,33H,8,10H2,(H,27,32)(H,28,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.02E+3	n/a	n/a	n/a	n/a	7.2	30
Medpacto, Inc. US Patent					Assay Description To check the B-Raf kinase inhibitory activity of the compounds of the present invention, the following experiments were conducted.(1) Serial Signalin...				US Patent US9216981 (2015) BindingDB Entry DOI: 10.7270/Q2BC3XCR
					More data for this Ligand-Target Pair