BDBM197709 US9216981, 38

SMILES: Fc1ccc(NS(=O)(=O)c2cccc3CCCOc23)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12

InChI Key: InChIKey=BZIPSTPBTUOWRZ-UHFFFAOYSA-N

Data: 1 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 197709   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM197709 (US9216981, 38) Show SMILES Fc1ccc(NS(=O)(=O)c2cccc3CCCOc23)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 Show InChI InChI=1S/C25H19F2N7O3S/c26-16-8-9-17(34-38(35,36)18-7-1-4-14-5-3-11-37-23(14)18)19(27)21(16)33-24-15(6-2-10-28-24)20-22-25(31-12-29-20)32-13-30-22/h1-2,4,6-10,12-13,34H,3,5,11H2,(H,28,33)(H,29,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7.19E+3	n/a	n/a	n/a	37
Medpacto, Inc. US Patent					Assay Description To check the B-Raf cell activity inhibitory capability of the compounds of the present invention, the following experiments were conducted in A375P...				US Patent US9216981 (2015) BindingDB Entry DOI: 10.7270/Q2BC3XCR
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Homo sapiens (Human))	BDBM197709 (US9216981, 38) Show SMILES Fc1ccc(NS(=O)(=O)c2cccc3CCCOc23)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12 Show InChI InChI=1S/C25H19F2N7O3S/c26-16-8-9-17(34-38(35,36)18-7-1-4-14-5-3-11-37-23(14)18)19(27)21(16)33-24-15(6-2-10-28-24)20-22-25(31-12-29-20)32-13-30-22/h1-2,4,6-10,12-13,34H,3,5,11H2,(H,28,33)(H,29,30,31,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	900	n/a	n/a	n/a	n/a	7.2	30
Medpacto, Inc. US Patent					Assay Description To check the B-Raf kinase inhibitory activity of the compounds of the present invention, the following experiments were conducted.(1) Serial Signalin...				US Patent US9216981 (2015) BindingDB Entry DOI: 10.7270/Q2BC3XCR
					More data for this Ligand-Target Pair