BDBM197734 BDBM197735::US10562916, Compound 125::US9216986, 2-[2-(5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-ethyl]-quinoline::US9801878, 2-[2-(5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-ethyl]-quinoline::US9834564, Compound 125

SMILES: Cc1ncc(C)n2nc(CCc3ccc4ccccc4n3)nc12

InChI Key: InChIKey=HFJAJRSXGFHBJL-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 197734   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PED10A (Homo sapiens (Human))	BDBM197734 (BDBM197735 | US10562916, Compound 125 | US9216986,...) Show SMILES Cc1ncc(C)n2nc(CCc3ccc4ccccc4n3)nc12 Show InChI InChI=1S/C18H17N5/c1-12-11-19-13(2)18-21-17(22-23(12)18)10-9-15-8-7-14-5-3-4-6-16(14)20-15/h3-8,11H,9-10H2,1-2H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9216986 (2015) BindingDB Entry DOI: 10.7270/Q2Z31XG5
					More data for this Ligand-Target Pair
PED10A (Homo sapiens (Human))	BDBM197734 (BDBM197735 | US10562916, Compound 125 | US9216986,...) Show SMILES Cc1ncc(C)n2nc(CCc3ccc4ccccc4n3)nc12 Show InChI InChI=1S/C18H17N5/c1-12-11-19-13(2)18-21-17(22-23(12)18)10-9-15-8-7-14-5-3-4-6-16(14)20-15/h3-8,11H,9-10H2,1-2H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9216986 (2015) BindingDB Entry DOI: 10.7270/Q2Z31XG5
					More data for this Ligand-Target Pair
3',5'-cyclic phosphodiesterase (Homo sapiens (Human))	BDBM197734 (BDBM197735 | US10562916, Compound 125 | US9216986,...) Show SMILES Cc1ncc(C)n2nc(CCc3ccc4ccccc4n3)nc12 Show InChI InChI=1S/C18H17N5/c1-12-11-19-13(2)18-21-17(22-23(12)18)10-9-15-8-7-14-5-3-4-6-16(14)20-15/h3-8,11H,9-10H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals, Inc. US Patent					Assay Description In one embodiment, the compounds provided herein were assayed for their ability to inhibit human PDE-10A. In one embodiment, the activities of the co...				US Patent US10562916 (2020) BindingDB Entry DOI: 10.7270/Q2N87D6K
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM197734 (BDBM197735 | US10562916, Compound 125 | US9216986,...) Show SMILES Cc1ncc(C)n2nc(CCc3ccc4ccccc4n3)nc12 Show InChI InChI=1S/C18H17N5/c1-12-11-19-13(2)18-21-17(22-23(12)18)10-9-15-8-7-14-5-3-4-6-16(14)20-15/h3-8,11H,9-10H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9801878 (2017) BindingDB Entry DOI: 10.7270/Q26Q20CD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM197734 (BDBM197735 | US10562916, Compound 125 | US9216986,...) Show SMILES Cc1ncc(C)n2nc(CCc3ccc4ccccc4n3)nc12 Show InChI InChI=1S/C18H17N5/c1-12-11-19-13(2)18-21-17(22-23(12)18)10-9-15-8-7-14-5-3-4-6-16(14)20-15/h3-8,11H,9-10H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9801878 (2017) BindingDB Entry DOI: 10.7270/Q26Q20CD
					More data for this Ligand-Target Pair
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM197734 (BDBM197735 | US10562916, Compound 125 | US9216986,...) Show SMILES Cc1ncc(C)n2nc(CCc3ccc4ccccc4n3)nc12 Show InChI InChI=1S/C18H17N5/c1-12-11-19-13(2)18-21-17(22-23(12)18)10-9-15-8-7-14-5-3-4-6-16(14)20-15/h3-8,11H,9-10H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	n/a	n/a
Sunovion Pharmaceuticals Inc. US Patent					Assay Description The activities of the compounds were determined using the Molecular Devices IMAP PDE Fluorescence Polarization assay using recombinant human PDE-10 e...				US Patent US9834564 (2017) BindingDB Entry DOI: 10.7270/Q2FF3VN4
					More data for this Ligand-Target Pair