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SMILES: COc1ccc2nc(CCc3nc4nc(C)cc(C)n4n3)ccc2c1

InChI Key: InChIKey=WULZGMJESGYPSN-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 197736   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779]


(Homo sapiens (Human))		BDBM197736
PNG
(US9216986, 2-[2-(5,7-Dimethyl-[1,2,4]triazolo[1,5-...)
Show SMILES COc1ccc2nc(CCc3nc4nc(C)cc(C)n4n3)ccc2c1
Show InChI InChI=1S/C19H19N5O/c1-12-10-13(2)24-19(20-12)22-18(23-24)9-6-15-5-4-14-11-16(25-3)7-8-17(14)21-15/h4-5,7-8,10-11H,6,9H2,1-3H3
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 170n/an/an/an/an/a25



H. Lundbeck A/S

US Patent


Assay Description
A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...

US Patent US9216986 (2015)


BindingDB Entry DOI: 10.7270/Q2Z31XG5
More data for this
Ligand-Target Pair