BDBM197770 US9216986, 6-[2-(5,8-Dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)-ethyl]-2,2-difluoro-[1,3]dioxolo[4,5-g]quinoline

SMILES: Cc1cnc(C)c2nc(CCc3ccc4cc5OC(F)(F)Oc5cc4n3)nn12

InChI Key: InChIKey=KAWKUSXEOQYISU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 197770   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
PED10A (Homo sapiens (Human))	BDBM197770 (US9216986, 6-[2-(5,8-Dimethyl-[1,2,4]triazolo[1,5-...) Show SMILES Cc1cnc(C)c2nc(CCc3ccc4cc5OC(F)(F)Oc5cc4n3)nn12 Show InChI InChI=1S/C19H15F2N5O2/c1-10-9-22-11(2)18-24-17(25-26(10)18)6-5-13-4-3-12-7-15-16(8-14(12)23-13)28-19(20,21)27-15/h3-4,7-9H,5-6H2,1-2H3	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	520	n/a	n/a	n/a	n/a	n/a	25
H. Lundbeck A/S US Patent					Assay Description A PDE10A assay may for example, be performed as follows: The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme...				US Patent US9216986 (2015) BindingDB Entry DOI: 10.7270/Q2Z31XG5
					More data for this Ligand-Target Pair