BDBM197978 US9221767, 2::US9926282, Example 2

SMILES: Fc1ccc2CN(Cc2c1)C(=O)Cc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12

InChI Key: InChIKey=AELUNVGWCJWFQX-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 197978   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM197978 (US9221767, 2 | US9926282, Example 2) Show SMILES Fc1ccc2CN(Cc2c1)C(=O)Cc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C24H18FN3O2/c25-19-10-9-17-13-28(14-18(17)12-19)22(29)11-15-5-7-16(8-6-15)23-20-3-1-2-4-21(20)24(30)27-26-23/h1-10,12H,11,13-14H2,(H,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	679	n/a	n/a	n/a	n/a	7.5	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				US Patent US9221767 (2015) BindingDB Entry DOI: 10.7270/Q2JW8CP3
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM197978 (US9221767, 2 | US9926282, Example 2) Show SMILES Fc1ccc2CN(Cc2c1)C(=O)Cc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C24H18FN3O2/c25-19-10-9-17-13-28(14-18(17)12-19)22(29)11-15-5-7-16(8-6-15)23-20-3-1-2-4-21(20)24(30)27-26-23/h1-10,12H,11,13-14H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM197978 (US9221767, 2 | US9926282, Example 2) Show SMILES Fc1ccc2CN(Cc2c1)C(=O)Cc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C24H18FN3O2/c25-19-10-9-17-13-28(14-18(17)12-19)22(29)11-15-5-7-16(8-6-15)23-20-3-1-2-4-21(20)24(30)27-26-23/h1-10,12H,11,13-14H2,(H,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM197978 (US9221767, 2 | US9926282, Example 2) Show SMILES Fc1ccc2CN(Cc2c1)C(=O)Cc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12 Show InChI InChI=1S/C24H18FN3O2/c25-19-10-9-17-13-28(14-18(17)12-19)22(29)11-15-5-7-16(8-6-15)23-20-3-1-2-4-21(20)24(30)27-26-23/h1-10,12H,11,13-14H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	7.5	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				US Patent US9221767 (2015) BindingDB Entry DOI: 10.7270/Q2JW8CP3
					More data for this Ligand-Target Pair