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SMILES: O=C(Cc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12)N1CCCc2ccccc12

InChI Key: InChIKey=SLUIREGPPRISKC-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 197983   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM197983 (US9221767, 34 | US9926282, Example 34) Show SMILES O=C(Cc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12)N1CCCc2ccccc12 Show InChI InChI=1S/C25H21N3O2/c29-23(28-15-5-7-18-6-1-4-10-22(18)28)16-17-11-13-19(14-12-17)24-20-8-2-3-9-21(20)25(30)27-26-24/h1-4,6,8-14H,5,7,15-16H2,(H,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.19E+4	n/a	n/a	n/a	n/a	7.5	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				US Patent US9221767 (2015) BindingDB Entry DOI: 10.7270/Q2JW8CP3
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM197983 (US9221767, 34 | US9926282, Example 34) Show SMILES O=C(Cc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12)N1CCCc2ccccc12 Show InChI InChI=1S/C25H21N3O2/c29-23(28-15-5-7-18-6-1-4-10-22(18)28)16-17-11-13-19(14-12-17)24-20-8-2-3-9-21(20)25(30)27-26-24/h1-4,6,8-14H,5,7,15-16H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM197983 (US9221767, 34 | US9926282, Example 34) Show SMILES O=C(Cc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12)N1CCCc2ccccc12 Show InChI InChI=1S/C25H21N3O2/c29-23(28-15-5-7-18-6-1-4-10-22(18)28)16-17-11-13-19(14-12-17)24-20-8-2-3-9-21(20)25(30)27-26-24/h1-4,6,8-14H,5,7,15-16H2,(H,27,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.55E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois at Chicago					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				J Med Chem 51: 3437-48 (2008) BindingDB Entry DOI: 10.7270/Q2445PSQ
					More data for this Ligand-Target Pair
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM197983 (US9221767, 34 | US9926282, Example 34) Show SMILES O=C(Cc1ccc(cc1)-c1n[nH]c(=O)c2ccccc12)N1CCCc2ccccc12 Show InChI InChI=1S/C25H21N3O2/c29-23(28-15-5-7-18-6-1-4-10-22(18)28)16-17-11-13-19(14-12-17)24-20-8-2-3-9-21(20)25(30)27-26-24/h1-4,6,8-14H,5,7,15-16H2,(H,27,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	553	n/a	n/a	n/a	n/a	7.5	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...				US Patent US9221767 (2015) BindingDB Entry DOI: 10.7270/Q2JW8CP3
					More data for this Ligand-Target Pair