BDBM198124 Panobinostat

SMILES: Cc1[nH]c2ccccc2c1CCNCc1ccc(C=CC(=O)NO)cc1

InChI Key: InChIKey=FPOHNWQLNRZRFC-ZHACJKMWSA-N

Data: 1 KI  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 198124   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Catalytic domain 2 (zCD2) (Danio rerio)	BDBM198124 (Panobinostat) Show SMILES Cc1[nH]c2ccccc2c1CCNCc1ccc(C=CC(=O)NO)cc1 |w:18.19| Show InChI InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+	GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	Article PubMed	1.40	-12.1	2.5	n/a	n/a	n/a	n/a	n/a	25
University of Pennsylvania,					Assay Description The fluorescence anisotropy assay was performed with fluorescein-labeled SAHA (fl-SAHA, gift of C. Fierke, University of Michigan) and measured using...				Nat Chem Biol 12: 741-747 (2016) Article DOI: 10.1038/nchembio.2134 BindingDB Entry DOI: 10.7270/Q2TH8KH1
					More data for this Ligand-Target Pair