null
SMILES: COc1cccc(c1)[C@@H](C)NC(=O)Nc1nc(cs1)-c1ccncc1
InChI Key: InChIKey=PZUHTMLHMMXBQW-GFCCVEGCSA-N
PDB links: 1 PDB ID matches this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM199303 (US9221808, 1bh) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB US Patent | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lee Moffitt Cancer Center and Research Institute, Inc. US Patent | Assay Description Attention was focused on exploring, in turn, the SAR around the phenyl ring A, branching and substitution at the benzylic position, urea linkage of 1... | US Patent US9221808 (2015) BindingDB Entry DOI: 10.7270/Q2Z036ZG | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM199303 (US9221808, 1bh) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Moffitt Cancer Center Curated by ChEMBL | Assay Description Inhibition of N-terminal GST-tagged ROCK1 (1 to 535) (unknown origin) using KKRPQRRSNVF as substrate after 1 hr by Z-Lyte-based FRET assay | Medchemcomm 3: 699-709 (2012) Article DOI: 10.1039/c2md00320a BindingDB Entry DOI: 10.7270/Q2571G0R | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM199303 (US9221808, 1bh) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Moffitt Cancer Center Curated by ChEMBL | Assay Description Inhibition of N-terminal GST-tagged ROCK2 (1 to 552) (unknown origin) using KKRPQRRSNVF as substrate after 1 hr by Z-Lyte-based FRET assay | Medchemcomm 3: 699-709 (2012) Article DOI: 10.1039/c2md00320a BindingDB Entry DOI: 10.7270/Q2571G0R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM199303 (US9221808, 1bh) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
H. Lee Moffitt Cancer Center and Research Institute, Inc. US Patent | Assay Description Attention was focused on exploring, in turn, the SAR around the phenyl ring A, branching and substitution at the benzylic position, urea linkage of 1... | US Patent US9221808 (2015) BindingDB Entry DOI: 10.7270/Q2Z036ZG | |||||||||||
More data for this Ligand-Target Pair |