BDBM200978 4,6-dimethyl-5-[2-methyl-4-(pyrido[3,4-b] pyrazin-5-yloxy)phenyl]pyridazin-3(2H)-one::US9540352, example 9

SMILES: Cc1cc(Oc2nccc3nccnc23)ccc1-c1c(C)n[nH]c(=O)c1C

InChI Key: InChIKey=SRAUKBMMFKQCIR-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 200978   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM200978 (4,6-dimethyl-5-[2-methyl-4-(pyrido[3,4-b] pyrazin-...) Show SMILES Cc1cc(Oc2nccc3nccnc23)ccc1-c1c(C)n[nH]c(=O)c1C |(.67,3.47,;.67,1.93,;-.67,1.15,;-.67,-.38,;-2,-1.15,;-2,-2.69,;-.67,-3.47,;-.67,-5,;-2,-5.78,;-3.33,-5,;-4.67,-5.78,;-6,-5,;-6,-3.47,;-4.67,-2.69,;-3.33,-3.47,;.67,-1.15,;2,-.38,;2,1.15,;3.33,1.93,;4.67,1.15,;4.67,-.38,;6,1.93,;6,3.47,;4.67,4.23,;4.67,5.78,;3.33,3.47,;2,4.23,)| Show InChI InChI=1S/C20H17N5O2/c1-11-10-14(27-20-18-16(6-7-23-20)21-8-9-22-18)4-5-15(11)17-12(2)19(26)25-24-13(17)3/h4-10H,1-3H3,(H,25,26)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	306	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Pfizer Inc. US Patent					Assay Description The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...				US Patent US9540352 (2017) BindingDB Entry DOI: 10.7270/Q2X34VND
					More data for this Ligand-Target Pair