BDBM200989 1-[4-(3,5-dimethyl-6-oxo-1,6- 4dihydropyridazin--yl)-3-methylphenoxy] isoquinoline-7-carbonitrile::US9540352, example 13

SMILES: Cc1cc(Oc2nccc3ccc(cc23)C#N)ccc1-c1c(C)n[nH]c(=O)c1C

InChI Key: InChIKey=DASJPWLODOGTCC-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 200989   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM200989 (1-[4-(3,5-dimethyl-6-oxo-1,6- 4dihydropyridazin--y...) Show SMILES Cc1cc(Oc2nccc3ccc(cc23)C#N)ccc1-c1c(C)n[nH]c(=O)c1C |(2,3.47,;2,1.93,;.67,1.15,;.67,-.38,;-.67,-1.15,;-.67,-2.69,;.67,-3.47,;.67,-5,;-.67,-5.78,;-2,-5.01,;-3.33,-5.78,;-4.67,-5.01,;-4.67,-3.47,;-3.33,-2.7,;-2,-3.47,;-6,-2.7,;-7.34,-1.93,;2,-1.15,;3.33,-.38,;3.33,1.15,;4.67,1.93,;6,1.15,;6,-.38,;7.34,1.93,;7.34,3.47,;6,4.23,;6,5.78,;4.67,3.47,;3.33,4.23,)| Show InChI InChI=1S/C23H18N4O2/c1-13-10-18(6-7-19(13)21-14(2)22(28)27-26-15(21)3)29-23-20-11-16(12-24)4-5-17(20)8-9-25-23/h4-11H,1-3H3,(H,27,28)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	334	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Pfizer Inc. US Patent					Assay Description The affinity of the compounds described herein was determined by competition binding assays similar to those described in Ryman-Rasmussen et al., Dif...				US Patent US9540352 (2017) BindingDB Entry DOI: 10.7270/Q2X34VND
					More data for this Ligand-Target Pair