BDBM20211 18, Ac-pTyr-Leu-cis-3,4-methanoPro-Gln-Thr-NH2-1::19, Ac-pTyr-Leu-cis-3,4-methanoPro-Gln-Thr-NH2-2::4-[(2S)-2-{[(2S)-1-[(1R,2S,5S)-2-{[(1S)-3-carbamoyl-1-{[(1S,2S)-1-carbamoyl-2-hydroxypropyl]carbamoyl}propyl]carbamoyl}-3-azabicyclo[3.1.0]hexan-3-yl]-4-methyl-1-oxopentan-2-yl]carbamoyl}-2-acetamidoethyl]phenoxyphosphonic acid
SMILES: CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
InChI Key: InChIKey=UQQQVGZCKOVSIT-TYZKDCSJSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal transducer and activator of transcription 3 (Mus musculus (mouse)) | BDBM20211![]() (18, Ac-pTyr-Leu-cis-3,4-methanoPro-Gln-Thr-NH2-1 |...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.11E+3 | n/a | n/a | n/a | n/a | 7.5 | 22 |
The University of Texas at Houston | Assay Description Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe... | J Med Chem 48: 6661-70 (2005) Article DOI: 10.1021/jm050513m BindingDB Entry DOI: 10.7270/Q2TH8JZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Signal transducer and activator of transcription 3 (Mus musculus (mouse)) | BDBM20211![]() (18, Ac-pTyr-Leu-cis-3,4-methanoPro-Gln-Thr-NH2-1 |...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 265 | n/a | n/a | n/a | n/a | 7.5 | 22 |
The University of Texas at Houston | Assay Description Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe... | J Med Chem 48: 6661-70 (2005) Article DOI: 10.1021/jm050513m BindingDB Entry DOI: 10.7270/Q2TH8JZF | |||||||||||
More data for this Ligand-Target Pair |