BDBM20233 4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-1-(benzylcarbamoyl)-3-carbamoylpropyl]carbamoyl}pyrrolidin-1-yl]-4-methyl-1-oxopentan-2-yl]carbamoyl}-2-acetamidoethyl]phenoxyphosphonic acid::40, Ac-pTyr-Leu-Pro-Gln-NHBn::CHEMBL194855
SMILES: CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1
InChI Key: InChIKey=NFPGIPGWWWWVDI-DZUOILHNSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal transducer and activator of transcription 3 (Homo sapiens (Human)) | BDBM20233 (4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-1-(benzylcarbamo...) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 409 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Texas M. D. Anderson Cancer Center Curated by ChEMBL | Assay Description Inhibition of Stat3 (unknown origin) by fluorescence polarization assay | J Med Chem 52: 2429-42 (2009) Article DOI: 10.1021/jm801491w BindingDB Entry DOI: 10.7270/Q28C9W4V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transcription Factor STAT3 (Mus musculus (mouse)) | BDBM20233 (4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-1-(benzylcarbamo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 409 | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Texas at Houston | Assay Description Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe... | J Med Chem 48: 6661-70 (2005) Article DOI: 10.1021/jm050513m BindingDB Entry DOI: 10.7270/Q2TH8JZF | |||||||||||
More data for this Ligand-Target Pair |