BDBM20508 1-(2-bromophenyl)-3-[(3R)-1-(5-cyanopyridin-2-yl)pyrrolidin-3-yl]urea::pyrrolidine urea analogue, 19
SMILES: Brc1ccccc1NC(=O)N[C@@H]1CCN(C1)c1ccc(cn1)C#N
InChI Key: InChIKey=GTKINJHCSQIPIG-CYBMUJFWSA-N
Data: 1 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human)) | BDBM20508 (1-(2-bromophenyl)-3-[(3R)-1-(5-cyanopyridin-2-yl)p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 200 | n/a | n/a | 7.2 | 25 |
GSK | Assay Description One day before the assay was performed, human TRPV1 expressed in 1321N1 astrocytoma cells were plated onto 96-well assay plates and grown until 2.5 h... | Bioorg Med Chem Lett 16: 3287-91 (2006) Article DOI: 10.1016/j.bmcl.2006.03.030 BindingDB Entry DOI: 10.7270/Q2125QX9 | |||||||||||
More data for this Ligand-Target Pair |