BDBM206116 US9255110, 29

SMILES: COc1cnc2c(cnn2c1)C(=O)Nc1cc(Cl)ccc1N1CCC(CO)CC1

InChI Key: InChIKey=UQOHPUUHINBJHK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 206116   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM206116 (US9255110, 29) Show SMILES COc1cnc2c(cnn2c1)C(=O)Nc1cc(Cl)ccc1N1CCC(CO)CC1 Show InChI InChI=1S/C20H22ClN5O3/c1-29-15-9-22-19-16(10-23-26(19)11-15)20(28)24-17-8-14(21)2-3-18(17)25-6-4-13(12-27)5-7-25/h2-3,8-11,13,27H,4-7,12H2,1H3,(H,24,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
ROCHE PALO ALTO LLC; HOFFMANN-LA ROCHE INC. US Patent					Assay Description Purified recombinant IRAK-4 protein was incubated with 250 uM synthetic peptide(KKARFSRFAGSSPSQSSMVAR) in 30 ul of kinase buffer including (20 mM MOP...				US Patent US9255110 (2016) BindingDB Entry DOI: 10.7270/Q2XG9PZ2
					More data for this Ligand-Target Pair