BDBM206726 US9260425, 488

SMILES: FC(F)(F)Cn1cc(cn1)-c1cc2c(n[nH]c2cn1)-c1cccc(n1)N1CCNCC1

InChI Key: InChIKey=MTNRQWRDLVCYQT-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 206726   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM206726 (US9260425, 488) Show SMILES FC(F)(F)Cn1cc(cn1)-c1cc2c(n[nH]c2cn1)-c1cccc(n1)N1CCNCC1 Show InChI InChI=1S/C20H19F3N8/c21-20(22,23)12-31-11-13(9-26-31)16-8-14-17(10-25-16)28-29-19(14)15-2-1-3-18(27-15)30-6-4-24-5-7-30/h1-3,8-11,24H,4-7,12H2,(H,28,29)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0220	n/a	n/a	n/a	n/a	n/a	n/a	7.2	n/a
Genetech, Inc. US Patent					Assay Description PIM-1, PIM-2, and PIM-3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Chiu, J....				US Patent US9260425 (2016) BindingDB Entry DOI: 10.7270/Q2RR1X3X
					More data for this Ligand-Target Pair