BDBM207566 US10501467, Example 11::US9260440, 11::US9617273, Example 11

SMILES: CC(C)C1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O

InChI Key: InChIKey=HYNAPDOTRWQEEH-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 207566   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM207566 (US10501467, Example 11 | US9260440, 11 | US9617273...) Show SMILES CC(C)C1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O Show InChI InChI=1S/C16H14FN3O/c1-7(2)8-3-11-15-13(4-8)19-20-16(21)10-5-9(17)6-12(18-11)14(10)15/h5-8H,3-4H2,1-2H3	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.30	n/a	n/a	n/a	n/a	8.0	n/a
BeiGene, Ltd. US Patent					Assay Description PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...				US Patent US9260440 (2016) BindingDB Entry DOI: 10.7270/Q2QV3KBD
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM207566 (US10501467, Example 11 | US9260440, 11 | US9617273...) Show SMILES CC(C)C1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O Show InChI InChI=1S/C16H14FN3O/c1-7(2)8-3-11-15-13(4-8)19-20-16(21)10-5-9(17)6-12(18-11)14(10)15/h5-8H,3-4H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
BeiGene, Ltd. US Patent					Assay Description Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...				US Patent US9260440 (2016) BindingDB Entry DOI: 10.7270/Q2QV3KBD
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM207566 (US10501467, Example 11 | US9260440, 11 | US9617273...) Show SMILES CC(C)C1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O Show InChI InChI=1S/C16H14FN3O/c1-7(2)8-3-11-15-13(4-8)19-20-16(21)10-5-9(17)6-12(18-11)14(10)15/h5-8H,3-4H2,1-2H3	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
BeiGene, Ltd. US Patent					Assay Description PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...				US Patent US9617273 (2017) BindingDB Entry DOI: 10.7270/Q2CN75ZV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM207566 (US10501467, Example 11 | US9260440, 11 | US9617273...) Show SMILES CC(C)C1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O Show InChI InChI=1S/C16H14FN3O/c1-7(2)8-3-11-15-13(4-8)19-20-16(21)10-5-9(17)6-12(18-11)14(10)15/h5-8H,3-4H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
BeiGene, Ltd. US Patent					Assay Description Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...				US Patent US9617273 (2017) BindingDB Entry DOI: 10.7270/Q2CN75ZV
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM207566 (US10501467, Example 11 | US9260440, 11 | US9617273...) Show SMILES CC(C)C1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O Show InChI InChI=1S/C16H14FN3O/c1-7(2)8-3-11-15-13(4-8)19-20-16(21)10-5-9(17)6-12(18-11)14(10)15/h5-8H,3-4H2,1-2H3	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	3.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM207566 (US10501467, Example 11 | US9260440, 11 | US9617273...) Show SMILES CC(C)C1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O Show InChI InChI=1S/C16H14FN3O/c1-7(2)8-3-11-15-13(4-8)19-20-16(21)10-5-9(17)6-12(18-11)14(10)15/h5-8H,3-4H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
BEIGENE, LTD. US Patent					Assay Description Tankyrase-2 enzymatic assay was conducted using commercial Tankyrase-2 Chemiluminescent Assay Kit (BPS Biosciences) and the protocol with the kit. GS...				US Patent US10501467 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FS5
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM207566 (US10501467, Example 11 | US9260440, 11 | US9617273...) Show SMILES CC(C)C1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O Show InChI InChI=1S/C16H14FN3O/c1-7(2)8-3-11-15-13(4-8)19-20-16(21)10-5-9(17)6-12(18-11)14(10)15/h5-8H,3-4H2,1-2H3	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	n/a	n/a	2.40	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 2 (Homo sapiens (Human))	BDBM207566 (US10501467, Example 11 | US9260440, 11 | US9617273...) Show SMILES CC(C)C1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O Show InChI InChI=1S/C16H14FN3O/c1-7(2)8-3-11-15-13(4-8)19-20-16(21)10-5-9(17)6-12(18-11)14(10)15/h5-8H,3-4H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase 1 (Homo sapiens (Human))	BDBM207566 (US10501467, Example 11 | US9260440, 11 | US9617273...) Show SMILES CC(C)C1Cc2[nH]c3cc(F)cc4c3c2c(C1)n[nH]c4=O Show InChI InChI=1S/C16H14FN3O/c1-7(2)8-3-11-15-13(4-8)19-20-16(21)10-5-9(17)6-12(18-11)14(10)15/h5-8H,3-4H2,1-2H3	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
BEIGENE, LTD. US Patent					Assay Description PARP-1 enzymatic assay was conducted using a method modified from HT F Homogeneous PARP Inhibition Assay Kit (Trevigen). 8.8 nM PARP-1 was pre-incuba...				US Patent US10501467 (2019) BindingDB Entry DOI: 10.7270/Q2Z89FS5
					More data for this Ligand-Target Pair