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SMILES: OCCCS(=O)(CCCO)=NC(=O)c1cncc(c1)C#Cc1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1

InChI Key: InChIKey=DOXMACFCSSZECR-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 208460   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM208460
PNG
(US9266869, 18)
Show SMILES OCCCS(=O)(CCCO)=NC(=O)c1cncc(c1)C#Cc1cccc(NC(=O)c2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C28H26F3N3O5S/c29-28(30,31)24-7-2-6-22(17-24)26(37)33-25-8-1-5-20(16-25)9-10-21-15-23(19-32-18-21)27(38)34-40(39,13-3-11-35)14-4-12-36/h1-2,5-8,15-19,35-36H,3-4,11-14H2,(H,33,37)
PDB
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KEGG

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PC cid
PC sid
UniChem
US Patent
n/an/a 4n/an/an/an/a7.430



Allergan, Inc.

US Patent


Assay Description
Biochemical KDR kinase assays were performed in 96 well microtiter plates that were coated overnight with 75 ug/well of poly-Glu-Tyr (4:1) in 10 mM P...

US Patent US9266869 (2016)


BindingDB Entry DOI: 10.7270/Q2NV9H33
More data for this
Ligand-Target Pair