null

SMILES: Fc1ccc(nc1)-c1ccn(CC2OCCN2C(=O)c2ccccc2-n2nccn2)n1

InChI Key: InChIKey=RJEDZMXVJSJGGM-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 208495   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208495 (US9266870, 11) Show SMILES Fc1ccc(nc1)-c1ccn(CC2OCCN2C(=O)c2ccccc2-n2nccn2)n1 |w:12.12| Show InChI InChI=1S/C21H18FN7O2/c22-15-5-6-17(23-13-15)18-7-10-27(26-18)14-20-28(11-12-31-20)21(30)16-3-1-2-4-19(16)29-24-8-9-25-29/h1-10,13,20H,11-12,14H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	252	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208495 (US9266870, 11) Show SMILES Fc1ccc(nc1)-c1ccn(CC2OCCN2C(=O)c2ccccc2-n2nccn2)n1 |w:12.12| Show InChI InChI=1S/C21H18FN7O2/c22-15-5-6-17(23-13-15)18-7-10-27(26-18)14-20-28(11-12-31-20)21(30)16-3-1-2-4-19(16)29-24-8-9-25-29/h1-10,13,20H,11-12,14H2	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17.5	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair