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SMILES: Cc1ccc(c(c1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cc1)-n1nccn1

InChI Key: InChIKey=GUQHPENKNGCHKL-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 208501   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208501 (US9266870, 17 | US9266870, 22) Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cc1)-n1nccn1 |w:13.15| Show InChI InChI=1S/C23H21FN6O2/c1-16-2-7-21(30-25-9-10-26-30)19(14-16)23(31)29-12-13-32-22(29)15-28-11-8-20(27-28)17-3-5-18(24)6-4-17/h2-11,14,22H,12-13,15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.10	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208501 (US9266870, 17 | US9266870, 22) Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cc1)-n1nccn1 |w:13.15| Show InChI InChI=1S/C23H21FN6O2/c1-16-2-7-21(30-25-9-10-26-30)19(14-16)23(31)29-12-13-32-22(29)15-28-11-8-20(27-28)17-3-5-18(24)6-4-17/h2-11,14,22H,12-13,15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin receptor type 2 (Homo sapiens (Human))	BDBM208501 (US9266870, 17 | US9266870, 22) Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cc1)-n1nccn1 |w:13.15| Show InChI InChI=1S/C23H21FN6O2/c1-16-2-7-21(30-25-9-10-26-30)19(14-16)23(31)29-12-13-32-22(29)15-28-11-8-20(27-28)17-3-5-18(24)6-4-17/h2-11,14,22H,12-13,15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46.7	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair
Orexin/Hypocretin receptor type 1 (Homo sapiens (Human))	BDBM208501 (US9266870, 17 | US9266870, 22) Show SMILES Cc1ccc(c(c1)C(=O)N1CCOC1Cn1ccc(n1)-c1ccc(F)cc1)-n1nccn1 |w:13.15| Show InChI InChI=1S/C23H21FN6O2/c1-16-2-7-21(30-25-9-10-26-30)19(14-16)23(31)29-12-13-32-22(29)15-28-11-8-20(27-28)17-3-5-18(24)6-4-17/h2-11,14,22H,12-13,15H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	7.4	37
TAISHO PHARMACEUTICAL CO., LTD US Patent					Assay Description The antagonistic activities of the test compounds on human orexin-1 receptor (hOX1R) and orexin-2 receptor (hOX2R) were measured by modifying from th...				US Patent US9266870 (2016) BindingDB Entry DOI: 10.7270/Q2J38RCP
					More data for this Ligand-Target Pair