BDBM209895 US9273014, 24

SMILES: NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(C3CC3)c2NC1=O

InChI Key: InChIKey=UGHSMELYSLKUPL-XLNZFTOWSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 209895   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Notch 3 intracellular domain (Notch 3) (Homo sapiens (Human))	BDBM209895 (US9273014, 24) Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(C3CC3)c2NC1=O |r,t:21| Show InChI InChI=1S/C28H28F6N4O3/c29-27(30,31)13-11-18(23(35)39)19(12-14-28(32,33)34)25(40)38-24-26(41)37-22-17(15-9-10-15)7-4-8-20(22)21(36-24)16-5-2-1-3-6-16/h1-8,15,18-19,24H,9-14H2,(H2,35,39)(H,37,41)(H,38,40)/t18-,19+,24+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.				US Patent US9273014 (2016) BindingDB Entry DOI: 10.7270/Q2KW5DVX
					More data for this Ligand-Target Pair
Notch 1 intracellular domain (Notch 1) (Homo sapiens (Human))	BDBM209895 (US9273014, 24) Show SMILES NC(=O)[C@@H](CCC(F)(F)F)[C@@H](CCC(F)(F)F)C(=O)N[C@H]1N=C(c2ccccc2)c2cccc(C3CC3)c2NC1=O |r,t:21| Show InChI InChI=1S/C28H28F6N4O3/c29-27(30,31)13-11-18(23(35)39)19(12-14-28(32,33)34)25(40)38-24-26(41)37-22-17(15-9-10-15)7-4-8-20(22)21(36-24)16-5-2-1-3-6-16/h1-8,15,18-19,24H,9-14H2,(H2,35,39)(H,37,41)(H,38,40)/t18-,19+,24+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company US Patent					Assay Description The pharmacological properties of the compounds of this invention may be confirmed by a number of biological assays.				US Patent US9273014 (2016) BindingDB Entry DOI: 10.7270/Q2KW5DVX
					More data for this Ligand-Target Pair