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SMILES: Clc1cc2C[C@H](NC(=O)c3ccccc3CC\C=C\COc1cc2)C(=O)NC1(CC1)C#N

InChI Key: InChIKey=WPHFOPFATFRZKN-HJGNZBPTSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 210835   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Procathepsin L


(Homo sapiens (Human))		BDBM210835
PNG
(US9290467, 5)
Show SMILES Clc1cc2C[C@H](NC(=O)c3ccccc3CC\C=C\COc1cc2)C(=O)NC1(CC1)C#N |r,t:18|
Show InChI InChI=1S/C25H24ClN3O3/c26-20-14-17-9-10-22(20)32-13-5-1-2-6-18-7-3-4-8-19(18)23(30)28-21(15-17)24(31)29-25(16-27)11-12-25/h1,3-5,7-10,14,21H,2,6,11-13,15H2,(H,28,30)(H,29,31)/b5-1+/t21-/m0/s1
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US Patent
n/an/a 9.60n/an/an/an/a6.5n/a



HOFFMANN—LA ROCHE INC.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...

US Patent US9290467 (2016)


BindingDB Entry DOI: 10.7270/Q2H130VZ
More data for this
Ligand-Target Pair