BDBM210873 US9290467, 43

SMILES: Clc1cc2C[C@H](NC(=O)c3cc(ccc3OCCCCOc1cc2)C1CNC1)C(=O)NC1(CC1)C#N

InChI Key: InChIKey=AHMOZPALEOADJV-QFIPXVFZSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 210873   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Procathepsin L (Homo sapiens (Human))	BDBM210873 (US9290467, 43) Show SMILES Clc1cc2C[C@H](NC(=O)c3cc(ccc3OCCCCOc1cc2)C1CNC1)C(=O)NC1(CC1)C#N |r| Show InChI InChI=1S/C27H29ClN4O4/c28-21-11-17-3-5-24(21)36-10-2-1-9-35-23-6-4-18(19-14-30-15-19)13-20(23)25(33)31-22(12-17)26(34)32-27(16-29)7-8-27/h3-6,11,13,19,22,30H,1-2,7-10,12,14-15H2,(H,31,33)(H,32,34)/t22-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	6.5	n/a
HOFFMANN—LA ROCHE INC. US Patent					Assay Description Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore wh...				US Patent US9290467 (2016) BindingDB Entry DOI: 10.7270/Q2H130VZ
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