BDBM2198 (3-(2-tert-Butyl-5-methyl-phenylsulfanyl)-4-hydroxy-6-isopropyl-6-phenethyl-5,6-dihydro-pyran-2-one::3-[(2-tert-butyl-5-methylphenyl)sulfanyl]-4-hydroxy-6-(2-phenylethyl)-6-(propan-2-yl)-5,6-dihydro-2H-pyran-2-one::CHEMBL372040::PD 178390 Analog 37
SMILES: CC(C)C1(CCc2ccccc2)CC(=O)C(Sc2cc(C)ccc2C(C)(C)C)C(=O)O1
InChI Key: InChIKey=FPODAFKDQIBIAN-UHFFFAOYSA-N
PDB links: 1 PDB ID contains this monomer as substructures. 1 PDB ID contains inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HIV-1 Protease (Human immunodeficiency virus type 1) | BDBM2198 ((3-(2-tert-Butyl-5-methyl-phenylsulfanyl)-4-hydrox...) | PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Parke-Davis Pharmaceutical Research | Assay Description For determination of IC50 values, HIV-1 protease was added to assay buffer containing inhibitor and the substrate (H-His-Lys-Ala-Arg-Val-Leu- (p-NO2)... | Bioorg Med Chem 7: 2775-800 (1999) Article DOI: 10.1016/s0968-0896(99)00215-1 BindingDB Entry DOI: 10.7270/Q21C1V2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Human immunodeficiency virus type 1 protease (Human immunodeficiency virus type 1) | BDBM2198 ((3-(2-tert-Butyl-5-methyl-phenylsulfanyl)-4-hydrox...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a |
Peking University Curated by ChEMBL | Assay Description Effective concentration required to inhibit human immunodeficiency virus 1 protease in MT-4 cells | Bioorg Med Chem Lett 15: 3257-62 (2005) Article DOI: 10.1016/j.bmcl.2005.04.057 BindingDB Entry DOI: 10.7270/Q20V8C9V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Human immunodeficiency virus type 1 protease (Human immunodeficiency virus type 1) | BDBM2198 ((3-(2-tert-Butyl-5-methyl-phenylsulfanyl)-4-hydrox...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Peking University Curated by ChEMBL | Assay Description Inhibitory concentration against human immunodeficiency virus 1 protease in MT-4 cells | Bioorg Med Chem Lett 15: 3257-62 (2005) Article DOI: 10.1016/j.bmcl.2005.04.057 BindingDB Entry DOI: 10.7270/Q20V8C9V | |||||||||||
More data for this Ligand-Target Pair |