BDBM220866 US9302986, 23
SMILES: CC(C)(C)NC(=O)c1ccc(OC\C(CN)=C\F)cc1
InChI Key: InChIKey=OWNSXNXYELKDSO-DHZHZOJOSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Amine oxidase [flavin-containing] B (Homo sapiens (Human)) | BDBM220866 (US9302986, 23) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | 7.4 | 37 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH US Patent | Assay Description Recombinant human MAO-B (0.06 mg/mL; Sigma Aldrich) was used as source of MAO-B enzyme activities. The assay was performed in a similar way as for hu... | US Patent US9302986 (2016) BindingDB Entry DOI: 10.7270/Q2ZC81QZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Membrane primary amine oxidase (Homo sapiens (Human)) | BDBM220866 (US9302986, 23) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | <1.00E+5 | n/a | n/a | n/a | n/a | 7.4 | n/a |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH US Patent | Assay Description Briefly, HMEC cell expressing human SSAO/VAP-1 were grown in several 10 cm petri dishes, once the cells reached 100% confluency, cells were harvested... | US Patent US9302986 (2016) BindingDB Entry DOI: 10.7270/Q2ZC81QZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Membrane primary amine oxidase (Homo sapiens (Human)) | BDBM220866 (US9302986, 23) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Astellas Pharma Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant VAP-1 using benzylamine as substrate incubated for 30 mins followed by substrate addition measured every 2.5 mins for... | Bioorg Med Chem 25: 187-201 (2017) Article DOI: 10.1016/j.bmc.2016.10.025 BindingDB Entry DOI: 10.7270/Q2XW4MS7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amiloride-sensitive amine oxidase [copper-containing] (Homo sapiens (Human)) | BDBM220866 (US9302986, 23) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.4 | 37 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH US Patent | Assay Description Recombinant human DAO (2.4 μg/mL) was used as source of DAO enzyme activities. The assay was performed as described in the method for human SSAO/V... | US Patent US9302986 (2016) BindingDB Entry DOI: 10.7270/Q2ZC81QZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Membrane primary amine oxidase (Rattus norvegicus (Rat)) | BDBM220866 (US9302986, 23) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | <1.00E+5 | n/a | n/a | n/a | n/a | 7.4 | n/a |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH US Patent | Assay Description Abdominal fat from BALB/c mice, Wistar or Sprague Dawley rats, which are tissues enriched with SSAO/VAP-1-were surgically removed. For every gram of ... | US Patent US9302986 (2016) BindingDB Entry DOI: 10.7270/Q2ZC81QZ | |||||||||||
More data for this Ligand-Target Pair |