BDBM221330 US9303023, 29

SMILES: COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4ccccc4F)cn3)c2c1

InChI Key: InChIKey=IHMCGUALJBZONR-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 221330   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221330 (US9303023, 29) Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4ccccc4F)cn3)c2c1 Show InChI InChI=1S/C24H20FN5O3/c1-32-17-6-7-21-19(10-17)15(11-26-21)8-9-30-13-16(12-28-30)29-24(31)22-23(33-14-27-22)18-4-2-3-5-20(18)25/h2-7,10-14,26H,8-9H2,1H3,(H,29,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair