BDBM221348 US9303023, 144

SMILES: COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4cc(C)no4)cn3)c2c1

InChI Key: InChIKey=ICDWCKYUKVRIPV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 221348   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221348 (US9303023, 144) Show SMILES COc1ccc2[nH]cc(CCn3cc(NC(=O)c4ncoc4-c4cc(C)no4)cn3)c2c1 Show InChI InChI=1S/C22H20N6O4/c1-13-7-19(32-27-13)21-20(24-12-31-21)22(29)26-15-10-25-28(11-15)6-5-14-9-23-18-4-3-16(30-2)8-17(14)18/h3-4,7-12,23H,5-6H2,1-2H3,(H,26,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair