BDBM221353 US9303023, 49

SMILES: COc1cc(OC)nc(NCCn2cc(NC(=O)c3ncoc3-c3ccc(C)c(C)c3)cn2)n1

InChI Key: InChIKey=UMRVJYKKUSVFLK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 221353   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221353 (US9303023, 49) Show SMILES COc1cc(OC)nc(NCCn2cc(NC(=O)c3ncoc3-c3ccc(C)c(C)c3)cn2)n1 Show InChI InChI=1S/C23H25N7O4/c1-14-5-6-16(9-15(14)2)21-20(25-13-34-21)22(31)27-17-11-26-30(12-17)8-7-24-23-28-18(32-3)10-19(29-23)33-4/h5-6,9-13H,7-8H2,1-4H3,(H,27,31)(H,24,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair