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SMILES: Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCc2c[nH]c3ccc(F)cc23)c1

InChI Key: InChIKey=YNDMVFGUMKKJMM-UHFFFAOYSA-N

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 221366   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Orexin receptor type 2


(Homo sapiens (Human))		BDBM221366
PNG
(US9303023, 62)
Show SMILES Cc1cccc(c1)-c1ocnc1C(=O)Nc1cnn(CCc2c[nH]c3ccc(F)cc23)c1
Show InChI InChI=1S/C24H20FN5O2/c1-15-3-2-4-16(9-15)23-22(27-14-32-23)24(31)29-19-12-28-30(13-19)8-7-17-11-26-21-6-5-18(25)10-20(17)21/h2-6,9-14,26H,7-8H2,1H3,(H,29,31)
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US Patent
n/an/a 98n/an/an/an/an/a37



ACTELION PHARMACEUTICALS LTD.

US Patent


Assay Description
Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...

US Patent US9303023 (2016)


BindingDB Entry DOI: 10.7270/Q2251H10
More data for this
Ligand-Target Pair