BDBM221434 US9303023, 131

SMILES: COc1ccnc(NCCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)n1

InChI Key: InChIKey=PWPAALYEKKOADW-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 221434   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221434 (US9303023, 131) Show SMILES COc1ccnc(NCCCn2cc(NC(=O)c3ncoc3-c3cccc(C)c3)cn2)n1 Show InChI InChI=1S/C22H23N7O3/c1-15-5-3-6-16(11-15)20-19(25-14-32-20)21(30)27-17-12-26-29(13-17)10-4-8-23-22-24-9-7-18(28-22)31-2/h3,5-7,9,11-14H,4,8,10H2,1-2H3,(H,27,30)(H,23,24,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair