BDBM221445 US9303023, 142

SMILES: COc1ccc2ccn(CCCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2c1

InChI Key: InChIKey=DICIKTWZAQMHFE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 221445   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Orexin receptor type 2 (Homo sapiens (Human))	BDBM221445 (US9303023, 142) Show SMILES COc1ccc2ccn(CCCn3cc(NC(=O)c4ncoc4-c4cccc(C)c4)cn3)c2c1 Show InChI InChI=1S/C26H25N5O3/c1-18-5-3-6-20(13-18)25-24(27-17-34-25)26(32)29-21-15-28-31(16-21)11-4-10-30-12-9-19-7-8-22(33-2)14-23(19)30/h3,5-9,12-17H,4,10-11H2,1-2H3,(H,29,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	37
ACTELION PHARMACEUTICALS LTD. US Patent					Assay Description Chinese hamster ovary (CHO) cells expressing the human orexin-1 receptor and the human orexin-2 receptor, respectively, are grown in culture medium (...				US Patent US9303023 (2016) BindingDB Entry DOI: 10.7270/Q2251H10
					More data for this Ligand-Target Pair