BDBM22194 2-(4-{2-[bis(4-fluorophenyl)methoxy]ethyl}piperazin-1-yl)-1-phenylethan-1-one::GBR 12935 Analogue, 23

SMILES: Fc1ccc(cc1)C(OCCN1CCN(CC(=O)c2ccccc2)CC1)c1ccc(F)cc1

InChI Key: InChIKey=PLTVEFQGFXRXRM-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 22194   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM22194 (2-(4-{2-[bis(4-fluorophenyl)methoxy]ethyl}piperazi...) Show SMILES Fc1ccc(cc1)C(OCCN1CCN(CC(=O)c2ccccc2)CC1)c1ccc(F)cc1 Show InChI InChI=1S/C27H28F2N2O2/c28-24-10-6-22(7-11-24)27(23-8-12-25(29)13-9-23)33-19-18-30-14-16-31(17-15-30)20-26(32)21-4-2-1-3-5-21/h1-13,27H,14-20H2	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	54	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Taiwan University					Assay Description The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...				J Med Chem 51: 2795-806 (2008) Article DOI: 10.1021/jm701270n BindingDB Entry DOI: 10.7270/Q2B27SK6
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM22194 (2-(4-{2-[bis(4-fluorophenyl)methoxy]ethyl}piperazi...) Show SMILES Fc1ccc(cc1)C(OCCN1CCN(CC(=O)c2ccccc2)CC1)c1ccc(F)cc1 Show InChI InChI=1S/C27H28F2N2O2/c28-24-10-6-22(7-11-24)27(23-8-12-25(29)13-9-23)33-19-18-30-14-16-31(17-15-30)20-26(32)21-4-2-1-3-5-21/h1-13,27H,14-20H2	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	88	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Taiwan University					Assay Description The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated...				J Med Chem 51: 2795-806 (2008) Article DOI: 10.1021/jm701270n BindingDB Entry DOI: 10.7270/Q2B27SK6
					More data for this Ligand-Target Pair