BDBM22245 2,4,5-tri-substituted imidazole, 14j::N-{2-[5-(4-methoxyphenyl)-2-(pyridin-2-yl)-1H-imidazol-4-yl]ethyl}-4-pentylbenzene-1-sulfonamide

SMILES: CCCCCc1ccc(cc1)S(=O)(=O)NCCc1[nH]c(nc1-c1ccc(OC)cc1)-c1ccccn1

InChI Key: InChIKey=ZQXWPKZXNHMHOV-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 22245   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 15-lipoxygenase (Oryctolagus cuniculus (rabbit))	BDBM22245 (2,4,5-tri-substituted imidazole, 14j | N-{2-[5-(4-...) Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCc1[nH]c(nc1-c1ccc(OC)cc1)-c1ccccn1 Show InChI InChI=1S/C28H32N4O3S/c1-3-4-5-8-21-10-16-24(17-11-21)36(33,34)30-20-18-25-27(22-12-14-23(35-2)15-13-22)32-28(31-25)26-9-6-7-19-29-26/h6-7,9-17,19,30H,3-5,8,18,20H2,1-2H3,(H,31,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	970	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...				Bioorg Med Chem Lett 17: 5115-20 (2007) Article DOI: 10.1016/j.bmcl.2007.07.011 BindingDB Entry DOI: 10.7270/Q2XW4H31
					More data for this Ligand-Target Pair