BDBM22251 2,4,5-tri-substituted imidazole, 14p::N-{3-[5-(4-methoxyphenyl)-2-(thiophen-2-yl)-1H-imidazol-4-yl]propyl}-4-pentylbenzene-1-sulfonamide

SMILES: CCCCCc1ccc(cc1)S(=O)(=O)NCCCc1[nH]c(nc1-c1ccc(OC)cc1)-c1cccs1

InChI Key: InChIKey=HLVHZCHBQXLZGI-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 22251   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 15-lipoxygenase (Oryctolagus cuniculus (rabbit))	BDBM22251 (2,4,5-tri-substituted imidazole, 14p | N-{3-[5-(4-...) Show SMILES CCCCCc1ccc(cc1)S(=O)(=O)NCCCc1[nH]c(nc1-c1ccc(OC)cc1)-c1cccs1 Show InChI InChI=1S/C28H33N3O3S2/c1-3-4-5-8-21-11-17-24(18-12-21)36(32,33)29-19-6-9-25-27(22-13-15-23(34-2)16-14-22)31-28(30-25)26-10-7-20-35-26/h7,10-18,20,29H,3-6,8-9,19H2,1-2H3,(H,30,31)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...				Bioorg Med Chem Lett 17: 5115-20 (2007) Article DOI: 10.1016/j.bmcl.2007.07.011 BindingDB Entry DOI: 10.7270/Q2XW4H31
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