BDBM22255 2,4,5-tri-substituted imidazole, 21c::4-(2-chlorophenyl)-N-{2-[5-(4-methoxyphenyl)-2-(thiophen-2-yl)-1H-imidazol-4-yl]ethyl}piperazine-1-sulfonamide

SMILES: COc1ccc(cc1)-c1nc([nH]c1CCNS(=O)(=O)N1CCN(CC1)c1ccccc1Cl)-c1cccs1

InChI Key: InChIKey=VDHKOWSRLQHFMY-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 22255   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 15-lipoxygenase (Oryctolagus cuniculus (rabbit))	BDBM22255 (2,4,5-tri-substituted imidazole, 21c | 4-(2-chloro...) Show SMILES COc1ccc(cc1)-c1nc([nH]c1CCNS(=O)(=O)N1CCN(CC1)c1ccccc1Cl)-c1cccs1 Show InChI InChI=1S/C26H28ClN5O3S2/c1-35-20-10-8-19(9-11-20)25-22(29-26(30-25)24-7-4-18-36-24)12-13-28-37(33,34)32-16-14-31(15-17-32)23-6-3-2-5-21(23)27/h2-11,18,28H,12-17H2,1H3,(H,29,30)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...				Bioorg Med Chem Lett 17: 5115-20 (2007) Article DOI: 10.1016/j.bmcl.2007.07.011 BindingDB Entry DOI: 10.7270/Q2XW4H31
					More data for this Ligand-Target Pair