BDBM224594 US10202383, Example 2(132)::US9321791, 2(132)::US9556175, 2(132)
SMILES: CC#CCn1c(nc2n(C)c(=O)n(Cc3ncc(C)c4ccccc34)c(=O)c12)N1CCC[C@@H](N)C1
InChI Key: InChIKey=MXOCXLWHNGNQEB-GOSISDBHSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM224594 (US10202383, Example 2(132) | US9321791, 2(132) | U...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.8 | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description 50 μl substrate solution (AFC; AFC is amido-4-trifluoromethylcoumarin), final concentration 100 μM, were placed in black microtitre plates. 20 ... | US Patent US9321791 (2016) BindingDB Entry DOI: 10.7270/Q2GQ6WNR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM224594 (US10202383, Example 2(132) | US9321791, 2(132) | U...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description 50 μl substrate solution (AFC; AFC is amido-4-trifluoromethylcoumarin), final concentration 100 μM, were placed in black microtitre plates.... | US Patent US10202383 (2019) BindingDB Entry DOI: 10.7270/Q2P55QNN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM224594 (US10202383, Example 2(132) | US9321791, 2(132) | U...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.8 | n/a |
Boehringer Ingelheim International GmbH US Patent | Assay Description 50 μl substrate solution (AFC; AFC is amido-4-trifluoromethylcoumarin), final concentration 100 μM, were placed in black microtitre plates.... | US Patent US9556175 (2017) BindingDB Entry DOI: 10.7270/Q2Z03B5T | |||||||||||
More data for this Ligand-Target Pair |