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SMILES: CNc1nnc(s1)-c1ccc2[nH]cc(-c3nccc(n3)N3CCOCC3)c2c1

InChI Key: InChIKey=MESZFHDSIOYFJC-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 224879   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-3 (Homo sapiens (Human))	BDBM224879 (US9321756, 134) Show SMILES CNc1nnc(s1)-c1ccc2[nH]cc(-c3nccc(n3)N3CCOCC3)c2c1 Show InChI InChI=1S/C19H19N7OS/c1-20-19-25-24-18(28-19)12-2-3-15-13(10-12)14(11-22-15)17-21-5-4-16(23-17)26-6-8-27-9-7-26/h2-5,10-11,22H,6-9H2,1H3,(H,20,25)	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	12.3	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9321756 (2016) BindingDB Entry DOI: 10.7270/Q2W094S2
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM224879 (US9321756, 134) Show SMILES CNc1nnc(s1)-c1ccc2[nH]cc(-c3nccc(n3)N3CCOCC3)c2c1 Show InChI InChI=1S/C19H19N7OS/c1-20-19-25-24-18(28-19)12-2-3-15-13(10-12)14(11-22-15)17-21-5-4-16(23-17)26-6-8-27-9-7-26/h2-5,10-11,22H,6-9H2,1H3,(H,20,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	16.3	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9321756 (2016) BindingDB Entry DOI: 10.7270/Q2W094S2
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM224879 (US9321756, 134) Show SMILES CNc1nnc(s1)-c1ccc2[nH]cc(-c3nccc(n3)N3CCOCC3)c2c1 Show InChI InChI=1S/C19H19N7OS/c1-20-19-25-24-18(28-19)12-2-3-15-13(10-12)14(11-22-15)17-21-5-4-16(23-17)26-6-8-27-9-7-26/h2-5,10-11,22H,6-9H2,1H3,(H,20,25)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	38.0	n/a	n/a	n/a	n/a	n/a	n/a
AMGEN INC. US Patent					Assay Description The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...				US Patent US9321756 (2016) BindingDB Entry DOI: 10.7270/Q2W094S2
					More data for this Ligand-Target Pair