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BDBM22636 N-Me-pyrimidone deriv., 35::N-[(4-fluorophenyl)methyl]-5-hydroxy-1-methyl-2-[1-methyl-4-(propan-2-yl)piperazin-2-yl]-6-oxo-1,6-dihydropyrimidine-4-carboxamide

SMILES: CC(C)N1CCN(C)C(C1)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C

InChI Key: InChIKey=FIYYRRFBOOVAHE-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 22636   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)		BDBM22636
PNG
(N-Me-pyrimidone deriv., 35 | N-[(4-fluorophenyl)me...)
Show SMILES CC(C)N1CCN(C)C(C1)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C
Show InChI InChI=1S/C21H28FN5O3/c1-13(2)27-10-9-25(3)16(12-27)19-24-17(18(28)21(30)26(19)4)20(29)23-11-14-5-7-15(22)8-6-14/h5-8,13,16,28H,9-12H2,1-4H3,(H,23,29)
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PC sid
UniChem

Similars
Article
PubMed
n/an/a 130n/an/an/an/an/an/a



IRBM-MRL



Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...

J Med Chem 50: 4953-75 (2007)


Article DOI: 10.1021/jm0704705
BindingDB Entry DOI: 10.7270/Q2BZ64BS
More data for this
Ligand-Target Pair