BDBM226447 US9328096, 140

SMILES: OCCNC(=O)c1cc(NC(=O)c2cc(-c3ccccn3)c(cc2Cl)C(F)(F)F)n(n1)-c1ccccc1

InChI Key: InChIKey=AJAIIHXDXVNPCD-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 226447   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM226447 (US9328096, 140) Show SMILES OCCNC(=O)c1cc(NC(=O)c2cc(-c3ccccn3)c(cc2Cl)C(F)(F)F)n(n1)-c1ccccc1 Show InChI InChI=1S/C25H19ClF3N5O3/c26-19-13-18(25(27,28)29)16(20-8-4-5-9-30-20)12-17(19)23(36)32-22-14-21(24(37)31-10-11-35)33-34(22)15-6-2-1-3-7-15/h1-9,12-14,35H,10-11H2,(H,31,37)(H,32,36)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at prolink-tagged TrkA (unknown origin) expressed in cells assessed as inhibition of NGF-induced receptor phosphorylation by meas...				J Med Chem 62: 247-265 (2019) Article DOI: 10.1021/acs.jmedchem.8b00280
					More data for this Ligand-Target Pair
Tyrosine kinase receptor A (TrkA) (Homo sapiens (Human))	BDBM226447 (US9328096, 140) Show SMILES OCCNC(=O)c1cc(NC(=O)c2cc(-c3ccccn3)c(cc2Cl)C(F)(F)F)n(n1)-c1ccccc1 Show InChI InChI=1S/C25H19ClF3N5O3/c26-19-13-18(25(27,28)29)16(20-8-4-5-9-30-20)12-17(19)23(36)32-22-14-21(24(37)31-10-11-35)33-34(22)15-6-2-1-3-7-15/h1-9,12-14,35H,10-11H2,(H,31,37)(H,32,36)	PDB GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	29.5	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...				US Patent US9328096 (2016) BindingDB Entry DOI: 10.7270/Q2FN152J
					More data for this Ligand-Target Pair