BDBM226502 US9328096, 195

SMILES: Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1COC1)-c1ccccn1

InChI Key: InChIKey=IVYVVPAINZAEEL-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 226502   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM226502 (US9328096, 195) Show SMILES Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1COC1)-c1ccccn1 Show InChI InChI=1S/C25H19Cl2N5O3/c26-19-11-20(27)18(10-17(19)21-8-4-5-9-28-21)24(33)30-23-12-22(25(34)29-15-13-35-14-15)31-32(23)16-6-2-1-3-7-16/h1-12,15H,13-14H2,(H,29,34)(H,30,33)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.90	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Antagonist activity at prolink-tagged TrkA (unknown origin) expressed in cells assessed as inhibition of NGF-induced receptor phosphorylation by meas...				J Med Chem 62: 247-265 (2019) Article DOI: 10.1021/acs.jmedchem.8b00280
					More data for this Ligand-Target Pair
Tyrosine kinase receptor A (TrkA) (Homo sapiens (Human))	BDBM226502 (US9328096, 195) Show SMILES Clc1cc(Cl)c(cc1C(=O)Nc1cc(nn1-c1ccccc1)C(=O)NC1COC1)-c1ccccn1 Show InChI InChI=1S/C25H19Cl2N5O3/c26-19-11-20(27)18(10-17(19)21-8-4-5-9-28-21)24(33)30-23-12-22(25(34)29-15-13-35-14-15)31-32(23)16-6-2-1-3-7-16/h1-12,15H,13-14H2,(H,29,34)(H,30,33)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	9.90	n/a	n/a	n/a	n/a	n/a	37
Pfizer Inc. US Patent					Assay Description TRKA co-expressed with p75: The assays are based upon DiscoveRx's proprietary Enzyme Fragment Complementation (EFC) technology. In the case of the TR...				US Patent US9328096 (2016) BindingDB Entry DOI: 10.7270/Q2FN152J
					More data for this Ligand-Target Pair