BDBM227167 US9328106, 114::US9328106, 122::US9328106, 132::US9328106, 133

SMILES: Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1C1CC(F)(F)CC(N)CO1

InChI Key: InChIKey=QYFKQWAZVKFMEO-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 227167   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227167 (US9328106, 114 | US9328106, 122 | US9328106, 132 |...) Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1C1CC(F)(F)CC(N)CO1 Show InChI InChI=1S/C20H20F4N6O2S/c1-30-16(13-6-20(23,24)5-9(25)8-32-13)12(7-27-30)28-18(31)15-17(26)33-19(29-15)14-10(21)3-2-4-11(14)22/h2-4,7,9,13H,5-6,8,25-26H2,1H3,(H,28,31)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0140	-14.8	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227167 (US9328106, 114 | US9328106, 122 | US9328106, 132 |...) Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1C1CC(F)(F)CC(N)CO1 Show InChI InChI=1S/C20H20F4N6O2S/c1-30-16(13-6-20(23,24)5-9(25)8-32-13)12(7-27-30)28-18(31)15-17(26)33-19(29-15)14-10(21)3-2-4-11(14)22/h2-4,7,9,13H,5-6,8,25-26H2,1H3,(H,28,31)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0140	-14.8	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227167 (US9328106, 114 | US9328106, 122 | US9328106, 132 |...) Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1C1CC(F)(F)CC(N)CO1 Show InChI InChI=1S/C20H20F4N6O2S/c1-30-16(13-6-20(23,24)5-9(25)8-32-13)12(7-27-30)28-18(31)15-17(26)33-19(29-15)14-10(21)3-2-4-11(14)22/h2-4,7,9,13H,5-6,8,25-26H2,1H3,(H,28,31)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0320	-14.3	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM227167 (US9328106, 114 | US9328106, 122 | US9328106, 132 |...) Show SMILES Cn1ncc(NC(=O)c2nc(sc2N)-c2c(F)cccc2F)c1C1CC(F)(F)CC(N)CO1 Show InChI InChI=1S/C20H20F4N6O2S/c1-30-16(13-6-20(23,24)5-9(25)8-32-13)12(7-27-30)28-18(31)15-17(26)33-19(29-15)14-10(21)3-2-4-11(14)22/h2-4,7,9,13H,5-6,8,25-26H2,1H3,(H,28,31)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0760	-13.8	n/a	n/a	n/a	n/a	n/a	7.2	25
GENENTECH, INC. US Patent					Assay Description LC3K assay: PIM-1, -2, and -3 enzymes were generated as fusion proteins expressed in bacteria and purified by IMAC column chromatography (Sun, X., Ch...				US Patent US9328106 (2016) BindingDB Entry DOI: 10.7270/Q29W0DBT
					More data for this Ligand-Target Pair